I Spent Those Years In the Operating Room Fighting Monsters

"Breakpoint research? How to say it?" Lu Cheng has advanced medical statistics, so when he heard Fang Nixin talk about breakpoint research, he still knew the term.

Breakpoint regression model.

But breakpoint regression is mostly used in social sciences!

Social scientists are primarily interested in causality.

In the social sciences, randomized trials are limited by a number of ethical and practical constraints. In the absence of randomized trials, we often resort to rigorous quasi-natural experimental interventions. Among them, the breakpoint regression method is a credible causal inference analysis method.

For example, analyze the impact of IQ and college entrance examination scores on a person.

This statistical method is rarely used in the field of natural sciences such as medicine.

Breakpoint regression is applicable to whether the use of an intervention method depends entirely on a continuous variable. For example, the use of hypoglycemic drugs depends on the blood sugar level. This continuous variable is equivalent to a discontinuous function, which completely determines whether an individual is affected by a specific intervention.

From 1984, trochim believed that the application of breakpoint regression was not so narrow, on the contrary, its application was very broad, and his findings expanded that the key variable that determines intervention can not only be a measured continuous variable, but also a measured continuous variable. synthetic variables.

After him, the advantages of breakpoint regression were gradually recognized by the academic community, and its application was more extensive.

Its advantages include two aspects: first, breakpoint regression can be applied to the constraints of research cost and ethical issues, and it can be used in cases where rct cannot be carried out; second, breakpoint regression is superior to all other known methods of causal inference , including the instrumental variable method, the results are very close to the results of random experiments.

Medical research is about objectivity and precision. Because a certain amount of error can cause different results.

Therefore, Lu Cheng hadn't considered this method before, because he was a clinician, and he didn't have so much free time to apply a statistical method that was mostly used in social sciences in this research group.

However, as Professor Min Hong said before, when your achievement in a subject reaches a certain threshold, you may need to read more books in other subjects, ask for help from other subjects, and you may have an epiphany.

Fang Nixin's message was very early, and Lu Cheng didn't reply to her, nor did she urge her.

But obviously during this period of time, she has made a lot of preparations herself, and her own scientific research qualifications are really better than Lu Cheng, so she sent a message saying:

"This is a question that came to my mind when I was doing bioinformatics analysis of the vi-related genotypes that I could find online."

"We can actually perform breakpoint regression analysis on existing patients. And we can only do breakpoint regression, not rct."

"We can use different grouping values ​​to analyze the length of hospitalization of patients and the diagnosis and treatment process of deceased patients."

"Breakpoint regression requires a highly idealized environment, but this kind of research obviously cannot be achieved through rct."

"In addition, we can also actively intervene through breakpoints in the process of doing cell experiments to explore the reproduction and growth rates of cells, and then analyze the pathways within them. Found some useful information..."

Fang Nixin sent a message, and then said, "This is my revised plan based on the experimental direction of our research group. Would you like to take a look?"

"Okay, send it over and I'll take a look." Lu Chengcheng went upstairs in no hurry.

Although I have scene skills, and Iris is helping me with experiments, and most of the experimental process is carried out in my own suggestions and discussions.

However, Lu Cheng did not dare to say that his research progress and research talent were better than others.

After carefully browsing, Lu Chengcheng immediately changed his direction.

Said: "You can print out two copies of this plan and the previous plan, and we will discuss it in detail."

The significance of the existence of the research group is to seek common ground while reserving differences.

Differences are inevitable, and everyone has different ideas and ideas. But Lu Cheng was always fighting alone before. Although others set up a temporary research group for him, but those people were not familiar with Lu Cheng, and what Lu Cheng released was too shocking.

For those who are not familiar with Lu Cheng, it is too late to confirm Lu Cheng's conjecture as soon as possible. How can they dare to make changes to Lu Cheng's existing plan?

Did Lu Cheng lose face or did they think they could do it?

Even if it is feasible, then drag them to Lu Cheng's position, and how many of them will be able to sit firmly?

At that time, Lu Cheng may not be able to help him with another basic design and let him change it. Lu Cheng is actually ordered in a critical situation.

This is the inevitable grudge that exists when the members of the research group are strangers.

But Fang Nixin is different. Her relationship with Lu Cheng should be one of the few people she is most familiar with. She can put forward her own ideas without any scruples, even if her ideas are adopted and valued .

She has been promoted, and she can still continue to work with Lu Cheng to propose the next research plan and continue the discussion.

For example, every time Lu Cheng wanted to announce any results, he would just go to Lin Hui as soon as possible, instead of going to Mr. Sheng and Mr. Gui, who were more famous than Lin Hui. The reason was the same.

Science knows no borders, but scientists do.

Just like at this special point in time, the research progress should not be concealed, it should be announced.

However, who will be announced, and how they will be announced, the research team can choose.

Once again, I came to an office on the 12th floor of the Science and Education Building. There are 5 floors away from the place where Fang Nixin experimented, and there are many floors in between.

The reason for this arrangement is that the laboratory must not be a place to live and live.

It has been temporarily transformed into a bedroom, just a simple single bed, and then there are necessary supplies such as a kettle. Of course, there is also a large table in the middle of the room, which used to be a desk.

At this moment, it has been cleaned out, and the table is more than two meters in all directions.

After Lu Cheng entered the door, he saw the so-called documents appearing on both sides of the desk. And on the side where Lu Cheng was, there was still a strong smell of alcohol, so Fang Nixin should have sterilized the appearance of this document.

Fang Nixin was taking off her gloves at the moment, pointed to the other side and said:

"You sit over there."

"The cup is clean, brought over after high temperature sterilization, and the water boiled for at least half an hour."

"I took the documents in examination gloves, and the stools were sterilized."

The current information about vi is that boiling water can kill vi, and it takes 30 minutes in a high temperature environment of 70 degrees.

When Lu Chengzheng was about to say something, Fang Nixin blocked his mouth in advance: "I'm here according to the current management method of researchers. I'm not strict. Let's talk about the topic first."

Lu Cheng nodded: "Well, good!"

At eleven o'clock in the middle of the night, the lights were transparent, and the two of them sat on the desk facing each other, starting a discussion between you and me.

Absolutely no rambling.

…

About half an hour later, Lu Cheng nodded and asked, "Fang Nixin, do you think this breakpoint return has a certain applicability among those who are currently undergoing treatment and recovering?"

Gu Qi

Fang Nixin said: "Recovery patients in the clinic can actually use retrospective rct analysis. There is absolutely no need to use breakpoint regression."

"The greater use of breakpoint regression is in more extreme conditions. Such as death, severe illness, disability..."

Can't you just kill people, **** them and get cramps just for the sake of research?

"Okay." Lu Cheng sighed with emotion, as if he was almost assimilated by the advantages of this breakpoint regression analysis just now, so he thought of applying everything to it.

Lu Cheng then changed the subject and said, "Fang Nixin, I have a series of data with a huge amount of data, and basic research design, you can use the computer to help me count it."

"I have already crawled out the data with a crawler, and it is already in excel format. You just need to analyze it."

Fang Nixin said suspiciously: "It's already in excel format, so you can analyze it. The most fearful thing is that the data has not yet been obtained, and the analysis cannot be analyzed."

However, when Fang Nixin saw clearly the data sent by Lu Cheng and the title of the word document.

"Statistical analysis of the retrospective analysis of the treatment process of 124,581 cases and theoretical support for guessing the predominant treatment plan."

I immediately understood what Lu Cheng meant.

Feeling a little guilty, he lowered his voice immediately: "Are you going to take my name?"

Fang Nixin is a sensible person. She has been in the research group before, and she is very clear about these ways.

The article brings several authors, or even gives one. Many people actually buy articles for the first author and corresponding author.

It's even too much. Huaguo also has a work for sci, and there are people who have dedicated themselves to it. You know how beneficial and tempting it is to have an extra name under these heavyweight studies.

"You are a member of the research group, and your contribution is the statistics and analysis of data. I will give you the crawler code later, and you can run it on your computer." Lu Chengcheng ensured that Fang Nixin could justifiably become a A part of this research is naturally well prepared.

Fang Nixin frowned: "This is not good? Others, won't you have any opinions?"

When Fang Nixin used to be in the research group, she was more used to people begging her to add a name, but now she was suddenly sent to one of the authors with great influence by Lu Cheng, and she still felt a little guilty.

"Now the leadership of our research group, it's you and me, and everyone else is concentrating on basic experiments."

"Okay, don't worry about it anymore. Your contribution to the research group is much greater than theirs." Lu Cheng quickly ended the topic.

Fang Nixin looked at Lu Cheng seriously, and said, "No, your student Dong Zhen, she may have more data and statistics than me. Even her attainments in mathematics are deeper than mine. ."

"It's just that my understanding in the field of medical research is slightly higher than hers. I think you can also pull her into the decision-making group, and maybe it will have other miraculous effects."

Girls like to be praised, but Fang Nixin only likes to be told that she is really good in some aspects.

For example, in clinical practice, she is very good at all departments, and her talent for research is also very high, but she is broad but not precise.

For example, she is beautiful, for example, she is smart, for example, she has a good figure.

But you have to say that she has money and can still make money.

She doesn't admit it.

She didn't feel that she was rich either. The money belonged to her brother and father, and she didn't make money by herself.

"These things about Dong Zhen? You know that too?" Lu Cheng was very surprised.

When she met Dong Zhen, wasn't Fang Nixin the hospital chief of Gu Si at that time? She is as tired as a dog every day, how does she have so much spare time to inquire about Dong Zhen?

"She is my student." Lu Cheng muttered and added.

Fang Nixin felt a little embarrassed and said, "I'm used to it, I'll definitely not next time."

Fang Nixin is really habitual to gossip about things around her. Through these gossip, she has established a relatively good and large network of contacts.

Otherwise, just because of Lu Cheng's relationship, when he heard Lu Cheng's name in the special ward, he asked Lu Cheng to see Fang Nixin?

Naturally, Fang Nixin had already gotten to know the people inside...

"Well, then you can send me this form tomorrow. You should only add a few key analysis forms, very soon. Then rest early."

Lu Cheng looked at the time: "It's almost half past twelve."

"No, I don't dare to delay it for so long. You have already made this kind of plan, just let me repeat it. If it is sent out one minute later, it may delay one minute of verification and one minute of trial implementation."

"I dare not delay. At the latest!"

Fang Nixin looked at the watch and made an estimate: "I'll take a break, I'll send it to you before 1:20, and then you can report it."

"This program is very important. It is a great supplement to the supplementation program you proposed before! Before specific anti-VI drugs are found, this is the best program sorted out by evidence-based medicine."

"Okay. Let's send it tonight."

Lu Cheng was helpless and could only nod his head.

When I was about to stand up.

Lu Cheng suddenly turned his head again and said, "Fang Nixin, why don't you go to bed now, in fact, before I came, I had set up a scheduled release in my mailbox. It's 1:00 in the morning today!"

Fang Nixin:…

His eyes glared at Lu Cheng.

You have made statistical analysis, what are you giving me back?

"If you are found out like this, you will be caught." Fang Nixin looked at Lu Cheng with a bit of ferocity, and made a gesture of wiping her neck.

"Not at all!"

"Every project and plan needs to be more detailed and careful, and it needs to be checked systematically. In our current research group, only you can check for me, doublecheck!"

"This is definitely not a waste of time, UU reading www.uukanshu.com sharpening knives does not cut firewood by mistake. If I make a small mistake and send it wrong, then it is called a crime."

"As you know, I can't post anything casually now. An expert group may be set up to stay up late to verify it. I can't burden those teachers." Lu Cheng said calmly, expounding a truth.

It is true that someone needs to double-check Lu Cheng, and even double-checking is not enough, preferably three or four.

It's just that Lu Cheng has checked the scene skills many times before, so there is basically no error...

At one o'clock in the morning, Lu Cheng chose to send it and called Director Huang. First of all, he apologized for disturbing him so late, but when Lu Cheng explained his intention, Director Huang was stunned.

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