I Spent Those Years In the Operating Room Fighting Monsters

That chapter was closed yesterday. . . .

Lu Cheng did not directly explain that plasmids that can be loaded with existing anti-specific targets would appear to be baseless.

And unfounded guidance, whether in front of his own students or in front of Zhou Linli and Ji Mo and other people, is unreasonable, and it will make them have a lot of doubts.

The reason why experiments can explain and discover nature is that it has a strong logic in itself.

From nothing, from one to two, from cause to effect.

From first discovering the phenomenon to deducing the essence, there is inherent logic in it.

Moreover, there are many ways to load specific target antagonistic drugs. Although plasmid antagonism is a better method, other methods are definitely not suitable.

But no matter what, as long as the current experiment goes well, Lu Cheng will be able to quickly resign as the current commander-in-chief.

Now that he has discovered a pathway, and has also found a target with strong adaptability, then the follow-up drug development, post-experiment and other processes can be taken over by others.

This will definitely be a very long-term battle process, and it cannot be done in one or two days.

For these time-consuming verification processes, there is no need to lock Lu Cheng here, and he can also give Lu Cheng a holiday.

After all, it had been more than a month since Lu Cheng first discovered the trace of VI. Although the current VI situation is still severe, the early discovery and multi-point and multi-source discovery were made in time, so the response was quite timely.

In addition, in the first time, there is a vaccine such as a vaccine, which is another big iron-blooded means to deal with VI.

"Okay, teacher."

"Okay, Mr. Lu."

"Okay, Lu Cheng." Dong Zhen and others, after getting the final result and Lu Cheng giving them the direction for the next step, hurriedly retreated.

They know that Lu Cheng is not a god, but Lu Cheng is the soul of this laboratory. From the beginning of the formation of this team, Lu Cheng has only been giving directions. The specific details are implemented by them.

It was they who filled in the details first according to the direction directed by Lu Cheng, and then discussed with Lu Cheng constantly, constantly changing the details, and then determined the direction and the specific steps to reach the direction.

In the process, they not only learned the corresponding operation skills, but also immersed in the process of how to carry out research on an unknown topic from scratch.

This is the most precious wealth.

experience, experience.

are two different concepts, but both are equally important.

At the end of the season, others began to fill in the details of the next topic.

Lu Chengcheng told Fang Nixin about this immediately.

Fang Nixin is still in isolation in her own laboratory. She will also carry out some small experiments. The small experiments are mainly to cooperate with Ji Mo and others to do some experiments that they have no time to do, or do not have time to do it, do a small experiment. small filling.

More time, Fang Nixin is actually doing data processing.

Because of her grasp of the entire subject, she is ahead of Ji Mo and others. Since Fang Nixin wants to be Lu Cheng's partner, she naturally needs to understand the progress of the research group and be ahead of the current progress. of.

Now, she has already begun to think, if this target is harmful to human cells, how to use the idea of ​​​​to seek advantages and avoid disadvantages.

Although she has done a lot of things and thinks a bit ahead of time, it doesn't hinder Fang Nixin when she heard the news, she immediately jumped up with joy: "Really? Lu Cheng?"

"The experimental results, are they so powerful?"

"I specially made a count of a control group. Without any drug intervention, VI's reproductive multiplier in 10 days is about 10 times the power of 3!"

"It's exponential growth and it's terrifying."

"Moreover, if there are enough infected cells at the first passage, they will cover the entire culture flask within 5 days, and then they will gather together into clusters around the seventh day, and then quickly consume the nutrients in the culture medium and successively Cracking."

"But now our processing result is 1.75!"

"It's equivalent to reducing the rate of reproduction to one-thousandth."

"If applied properly, this target is very feasible." Fang Nixin is a very understanding person, so she is very excited.

This is sure to be a groundbreaking move that will shock everyone for their team. And Fang Nixin was also a participant, and during the whole process, Fang Nixin did not feel that she was making soy sauce, and her contribution was second only to Lu Cheng.

She was not taken away.

This sense of achievement is naturally unimaginable for ordinary people.

Lu Chengdao: "Yes, but it is extremely difficult to build a carrier that carries specific target antagonist drugs into the body."

"It should also be taken into account that if this carrier has any defects, it will be an unimaginable blow to some cells of the human body!"

"That side effect is no less than chemotherapy."

In addition to considering the applicability of this target, Lu Cheng naturally also considers its limitations.

Today's cancer chemotherapy drugs, why are not very effective. One reason is that the inhibitory or killing effect on tumors is not strong, and the other reason is that it is also harmful to the human body.

Some CA patients cannot tolerate chemotherapy.

Moreover, the target specificity of CA in different people is different, so naturally it cannot be the same.

Fang Nixin nodded and said, "Well, this matter has to be taken slowly. We have found the existing specific targets, and with such a strong anti-VI effect, we have achieved the goal of our research group."

"As for the follow-up drug development, it has to be handed over to higher-level people. This is not something we can contact now."

Now, the research group that Lu Cheng and Fang Nixin belong to can definitely apply for the corresponding patent, and they will certainly apply for it. However, in the follow-up use of this kind of patent, Lu Cheng and Fang Nixin do not plan to keep it. .

Because VI is not a conventional disease, it is a catastrophic one.

This kind of money is not easy to make.

"Lu Cheng, do you think it's possible for us to be in textbooks?"

"History?" Fang Nixin asked suddenly.

Hearing this, Lu Cheng shook his head and said, "It depends on how you deal with VI. If you can, you can go up, if you don't, you can't go up."

"Fang Nixin, I'll talk to you later. I'll call my master first. Tell him the current good news." Lu Cheng then interrupted the chat.

Fang Nixin also nodded simply: "It should be."

After Lu Cheng hung up the phone, he called Lin Hui.

Lin Hui is drinking tea at the moment, so he is in a good mood: "Little Lu, but I haven't called for two days. How are you now?"

"The results are out, Master."

"The inhibitory effect of this specific target is very strong, reducing the reproduction rate by at least 1,000 times!" Lu Cheng said calmly.

Lin Hui immediately became very loud: "How much did you say?"

Lin Hui thought he had heard it wrong.

Generally speaking, the initial drug should not be a therapeutic drug, but should be an adjuvant therapeutic drug, which can prolong the reproduction cycle of VI and avoid its rapid reproduction and cause severe disease, which is excellent.

Lin Hui has done drug research on bone tumors before, so he is very clear about this aspect.

And such a drug, which prolongs the reproductive cycle to ten times the previous one, is the sky. Most of them are 5-7 times like this.

Because the cell culture period of the general basic experiment is about three days.

The reproductive cycle is extended by more than 50 times, which is a more sensitive drug.

More than 100 times, it is a special effect drug.

"It looks like 1,000." Lu Cheng said.

Lin Hui understood this time. He was stunned for a while, and then asked, "Lu Cheng, let's have a private chat with master and apprentice. You haven't reported this to the top, have you?"

"I ask you, have you found a normal structural target for cells?"

It makes sense for Lin Hui to ask this question. Normal cells are eukaryotic cells, with mitochondria and nuclei.

If Lu Cheng is looking for this kind of target, let alone 1000 times, 10000 times can be done, just use a nuclear bomb level to push everything on the horizon.

But such experiments are meaningless.

It would be too simple if the treatment of diseases could only consider whether the pathogen will die, but not whether the person will die.

There are simply not too many ways.

Then why do you need drugs? Physical therapy is enough.

Bake it at a high temperature of 1000 degrees, and irradiate it with super ultraviolet rays for 30 minutes!

Don't say it's VI, it's CA, and Iron Man has to die.

VI must die.

Lu Cheng also heard Lin Hui's concern, and quickly explained, "Master, that's not the case."

"This target belongs to a relatively special transcriptional target, or is related to the lncRNA in the transcriptional target. There are some cells in the human body that have such a transcriptional method, but most of them only accumulate in the liver and kidney. In organs such as the heart and lungs, temporary No relevant reports have been found.”

"Although it cannot be ruled out that other organs also have such transcription, but only a part of the functions are affected, and other normal cell functions can still operate normally. It's just that they can't proliferate in a short time." Lu Chengcheng put the key to simplicity. explained again.

It's not very detailed, because Lin Hui can definitely understand it.

Lin Hui really frowned: "Then the first contraindication of your drug research is liver and kidney insufficiency. And there are side effects of liver and kidney damage?"

"Do you plan to think about ways to avoid these contraindications that exist from a strictly theoretical level in the past?"

Lu Cheng replied, "I'm still thinking about it, but I plan to apply with Director Huang and the others to give you the position of commander-in-chief."

"I have finished all the key parts that I can do, and some of the follow-up questions are all about the timeline. I mean I don't want to go deeper into it."

"Master, what do you mean?" Although Lu Cheng made up his mind, he still decided to listen to Lin Hui's opinion.

Lin Hui pondered for a moment, then asked with a smile: "You can apply for a patent later, to set up a company, and you can get a small share of the shares with the patent. You don't plan to make it available in advance, and start business as soon as possible. ?"

The gradual industrialization of academic construction and professionalism is a very hot topic recently.

With the increase in the number of patents in China and the improvement of scientific research capabilities, this aspect has gradually begun to be valued.

Patent investment and core technology investment have gradually become popular.

Lin Hui simply ate this kind of sweetness, but he donated a large part of these sweetness, but the remaining part was enough for him to be rich and rich.

"Master, I believe there must be many people, for various reasons, who will make it appear as soon as possible, so I don't want to mix it up."

"And in fact, originally, I just wanted to do what a doctor should do. But I didn't expect that I gradually came to the point where I couldn't help myself."

"Then I was pressed step by step, and every step I took, I had to carefully and gradually test it out. I found that I was very unsuitable for this way of life and work mode. What I prefer is still clinically, and I can use my hands and feet freely. ."

"And even if we do research and basic experiments in the future, we definitely don't do any more experiments in this area."

"The pressure is too much!" Lu Cheng was telling the truth.

The sudden arrival of the unknown VI made Lu Cheng feel very real, don't be restrained, all kinds of uncomfortable feeling of being restrained and being pushed away.

But there was no other way, he got up, he could only let the rope out, and he had to go down to the end.

"Haha." Lin Hui smiled and then joked.

"You feel restrained, others feel it is enjoyment. Envy can't be envied."

"Corresponding to risk is opportunity!"

"This is a very popular phrase recently."

What Lin Hui said was very meaningful and meant something.

Lu Cheng didn't answer Lin Hui's words, he didn't bother to think about such a mess.

Although similar situations may be encountered in the future, UU reading www. uukanshu.com But that's for later. Lu Cheng is really not good at it, and he is not willing to exchange anything for such things.

So he said: "Master, I told Director Huang, I'm going to rest and go to lazy things."

"You kid." Lin Hui said with a smile.

"Actually, you can call and talk, or not. No matter what, so far, I have been the chief dispatcher of the experiment. You just took over from me for a while."

"This is also to protect you. Master doesn't want what happened to me before to happen to you again."

"However, the people at the top all know what you do, so the credits and rewards that should belong to you will not be missing from you."

Hearing this, Lu Cheng was stunned.

Ask: "Master? What do you mean?"

"Science knows no borders, but scientists do."

"You can't deal with scientific results, but you can deal with people who are related to scientific results."

"Of course, so far, such a thing has not happened, but it is still worth 100% precaution and 100% vigilance."

"Stop talking, you should go to rest early."

"I will send you a document later, which contains the topics and research you have done in detail. You need to be very familiar with the content and be recited, because that is when the anti-VI drug company was formally established. A superficial feat."

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